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Letrozole

Letrozole

€78.00

Excl. VAT

Item no.	HY-14248-100mg
Manufacturer	MedChem Express
CASRN	112809-51-5
Amount	100 mg
Category	Oncology Food Safety Hormones Inhibitors & Compound Libraries Small Molecules By Organ Breast Cancer Uterine, Ovarian & Cervical Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.92
Formula	C17H11N5
Citations	[1]Bhatnagar AS, et, al. Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor. J Steroid Biochem Mol Biol. 1990 Dec 20;37(6):1021-7. [2]Mitropoulou TN, et, al. Letrozole as a potent inhibitor of cell proliferation and expression of metalloproteinases (MMP-2 and MMP-9) by human epithelial breast cancer cells. Int J Cancer. 2003 Mar 20;104(2):155-60. [3]Schieweck K, et, al. Anti-tumor and endocrine effects of non-steroidal aromatase inhibitors on estrogen-dependent rat mammary tumors. J Steroid Biochem Mol Biol. 1993 Mar;44(4-6):633-6.
Smiles	N#CC1=CC=C(C(N2C=NC=N2)C3=CC=C(C#N)C=C3)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CGS 20267
Available
Product Description	Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	285.30
Clinical Information	Launched
Solubility	DMSO : 50 mg/mL (ultrasonic)
Isoform	Aromatase/CYP19A1
Pathway	Autophagy; Metabolic Enzyme/Protease
Manufacturers Product type	Natural Products

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-14248-100mg-safety-datasheet.pdf