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GSK189254A

GSK189254A

€443.00

Excl. VAT

Item no.	HY-14111-50mg
Manufacturer	MedChem Express
CASRN	720690-73-3
Amount	50 mg
Category	Oncology Food Safety Histamines Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Lipoprotein Receptors & Associated Proteins Lipid & Fatty Acid Transport Inhibitors & Compound Libraries Small Molecules By Organ Brain Cancer
Type	Inhibitors
Purity	98.09
Formula	C21H25N3O2
Citations	[1]Medhurst AD, et al. GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. J Pharmacol Exp Ther. 2007 Jun;321(3):1032-45. [2]Guo RX, et al. Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice.Br J Pharmacol. 2009 May;157(1):104-17.
Smiles	O=C(NC)C(C=N1)=CC=C1OC2=CC(CC3)=C(C=C2)CCN3C4CCC4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	GSK189254
Available
Product Description	GSK189254A (GSK189254) is a novel, potent and selective histamine H3 receptor antagonist with pKi values of 9.59-9.90 and 8.51-9.17 for human and rat H3, respectively.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neurodegeneration
Molecular Weight	351.44
Clinical Information	Phase 2
Solubility	DMSO : 25 mg/mL (ultrasonic)
Isoform	H3 Receptor
Pathway	GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-14111-50mg-safety-datasheet.pdf