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ICI 118,551 hydrochloride

ICI 118,551 hydrochloride

€104.00

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Item no.	HY-13951-10mM
Manufacturer	MedChem Express
CASRN	72795-01-8
Amount	10 mM/1 mL
Category	Metabolism Diabetes Glucose Homeostasis Cardiovascular Research Myocardial Infarction Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.76
Formula	C17H28ClNO2
Citations	Biomed Pharmacother. 2023 Mar 15;161:114523. bioRxiv. 2020 Jan. BMC Ophthalmol. 2021 Dec 5;21(1):419. BMC Cancer. 2019 Nov 26;19(1):1142. Br J Pharmacol. 2020 Jan;177(2):282-297. Commun Biol. 2021 Dec 3;4(1):1359. Commun Biol. 2022 Apr 8;5(1):339. Environ Toxicol. 2023 Dec 2. Eur J Pharmacol. 2022 Jun 20;175110. Int J Biol Sci. 2023 Apr 2,19. J Exp Clin Cancer Res. 2019 Apr 25;38(1):174. J Exp Med. 2023 Nov 6;220(11):e20230577. J Nutr Biochem. 2018 May 1;58:110-118. J Oral Maxillofac Surg. 2020 Oct;78(10):1871.e1-1871.e23. J Pharm Anal. 2024 Jan 4. Mol Oncol. 2022 May 20. Nat Commun. 2020 Sep 25;11(1):4857. Nat Commun. 2021 Nov 26;12(1):6937. Neuroscience. 2019 Mar 1;401:59-72. Oncol Rep. 2016 Sep;36(3):1576-84. Pflugers Arch. 2021 Sep 26. Research Square Preprint. 2020 Oct. Research Square Preprint. 2021 Feb. Research Square Preprint. 2021 Nov. Research Square Preprint. 2021 Sep. Research Square Preprint. 2022 Mar. J Endocrinol. 2023 Feb 16;256(3):e220335. Nat Commun. 2023 May 2;14(1):2523. [1]Hoffmann C, et al. Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):151-9. [2]Yasuda G, et al. The beta 1- and beta 2-adrenoceptor subtypes in cultured rat inner medullary collecting duct cells. Am J Physiol. 1996 Sep;271(3 Pt 2):F762-9. [3]Gong H, et al. Specific beta(2)AR blocker ICI 118,551 actively decreases contraction through a G(i)-coupled form of the beta(2)AR in myocytes from failing human heart. Circulation. 2002 May 28;105(21):2497-503. [4]Wenzel D, et al. beta(2)-adrenoceptor antagonist ICI 118,551 decreases pulmonary vascular tone in mice via a G(i/o) protein/nitric oxide-coupled pathway. Hypertension. 2009 Jul;54(1):157-63.
Smiles	CC1=C(CCC2)C2=C(OC[C@H](O)[C@@H](C)NC(C)C)C=C1.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ICI-118551 (hydrochloride)
Available
Product Description	Zenidolol (ICI-118551) hydrochloride is a highly selective β2 adrenergic receptor antagonist, with Kis of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
Molecular Weight	313.86
Clinical Information	No Development Reported
Solubility	DMSO : 33.33 mg/mL (ultrasonic)\|H2O : 12.5 mg/mL (ultrasonic)
Isoform	β adrenergic receptor
Pathway	GPCR/G Protein; Neuronal Signaling
Manufacturers Product type	Reference compound

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HY-13951-10mM-safety-datasheet.pdf