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Pemetrexed disodium hemipenta hydrate

Pemetrexed disodium hemipenta hydrate

€142.00

Excl. VAT

Item no.	HY-13781-500mg
Manufacturer	MedChem Express
CASRN	357166-30-4
Amount	500 mg
Category	Oncology Neuroscience Neural Lineage Markers Targets for Rodent Neurosciences Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Oligodendrocyte Markers
Type	Inhibitors
Purity	99.72
Formula	C20H24N5Na2O8.5
Citations	J Mol Med (Berl). 2019 Aug;97(8):1183-1193. Acta Pharmacol Sin. 2021 Jan;42(1):108-114. Br J Cancer. 2023 Jun 27. Cell Death Discov. 2022 Jul 5;8(1):307. Cell Rep Med. 2023 Jan 10;100911. Commun Biol. 2022 Jun 23;5(1):619. Int Immunopharmacol. 2023 Nov 3;125(Pt A):111158. J Clin Invest. 2021 Aug 2;131(15):e138022. J Control Release. 2022 Dec 9;353:490-506. Pharmacol Res Perspect. 2020 Apr;8(2):e00575. Research Square Print. September 27th, 2022. Theranostics. 2020 May 15;10(13):6048-6060. Beilstein J Org Chem. 2017 Oct 25;13:2252-2263. Clin Transl Oncol. 2022 Jul 19. Faculty of the Graduate School of Biomedical Sciences. The University of Texas Southwestern Medical Center. Oct 1. 2015. J Mol Med (Berl). 2019 Aug;97(8):1183-1193. Mol Cell. 2019 Dec 5;76(5):838-851.e5. Odontology. 2020 Apr;108(2):300-311. [1]Shih C, et al. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. 1997 Mar 15;57(6):1116-23. [2]Anraku M, et al. Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignantmesothelioma. J Immunol. 2010 Jul 15;185(2):956-66.
Smiles	O=C(O[Na])CC[C@@H](C(O[Na])=O)NC(C1=CC=C(CCC2=CNC(N=C(N)N3)=C2C3=O)C=C1)=O.[2.5H2O]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	LY231514 (disodium hemipenta hydrate)
Available
Product Description	Pemetrexed disodium hemipenta hydrate is a novel antifolate, the Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	516.41
Clinical Information	Launched
Solubility	DMSO : 2 mg/mL (ultrasonic)\|H2O : 100 mg/mL (ultrasonic)
Pathway	Apoptosis; Autophagy; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-13781-500mg-safety-datasheet.pdf