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Ionomycin

Ionomycin

€49.00

Excl. VAT

Item no.	HY-13434-1mg
Manufacturer	MedChem Express
CASRN	56092-81-0
Amount	1 mg (14.1 mM x 100 ul in Ethanol)
Category	Cell Biology Cell Status Apoptosis Cardiovascular Research Ischemia & Reperfusion Injury Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.0
Formula	C41H72O9
Citations	ACS Infect Dis. 2023 Mar 14. Acta Pharmacol Sin. 2022 Sep 23. Adv Sci (Weinh). 2023 Jan 15;e2203869. Aging. 2019 Aug 19;11(16):6490-6502. Aging. 2021 Jun 2;13(11):15638-15658. Aging. 2021 Mar 24;13(7):10312-10325. Biochem Pharmacol. 2023 Dec 2:115957. Biomed Pharmacother. 2022 Jan 17;147:112644. BMC Med. 2023 Dec 20;21(1):507. Cancer Cell. 2023 Jun 12;41(6):1170-1185.e12. Cancer Commun (Lond). 2022 Jan 3. Cancer Res. 2023 Jan 12;CAN-22-2405. Cell Calcium. 2022 Jun;104:102571. Cell Death Dis. 2021 Apr 1;12(4):336. Cell Mol Immunol. 2022 Feb 22. Cell Rep. 2021 Jul 20;36(3):109404. Ecotoxicol Environ Saf. 2023 Dec 14:115831. Eur J Pharmacol. 2021 Nov 9;174623. Evid-Based Compl Alt. 2021 Jan 7. Front Immunol. 05 August 2022. Int Immunopharmacol. 2023 Sep 1;124(Pt A):110865. Int J Biol Macromol. 2023 Jun 13;125373. Int J Mol Sci. 2023 Aug 8, 24(16), 12557. J Ethnopharmacol. 2022 Dec 8;303:116031. J Immunol. 2021 Mar 1;206(5):963-977. J Neuroimmunol. 2020 Aug 15;345:577286. Microorganisms. 2023 Feb 27. Mol Cell. 2022 May 5;S1097-2765(22)00327-6. Nat Commun. 2023 Feb 23;14(1):1020. Oncol Rep. 2024 Feb;51(2):29. Preprints. 2023 Mar 6. Proc Natl Acad Sci U S A. 2022 Feb 22;119(8):e2114851119. Protein Cell. 2021 Oct 22;1-21. Redox Biol. 2023 Nov 10, 102959. Reprod Fert Develop. 33(2) 108-108. Research Square Preprint. 2023 Aug 11. Research Square Print. 2022 Jun. Sci Signal. 2023 Feb 28;16(774):eadd0645. Sci Total Environ. 2021, 146523. Sci Transl Med. 2020 Nov 25;12(571):eaaz6667. Theranostics. 2023 May 8;13(9):2879-2895. Vaccines. 2023 May 25, 11(6), 1026. Int Immunopharmacol. 2023 Nov 16:126:111212. OncoImmunology. 2023 Oct 12;12(1):2268257. [1]Stoeck A, et al A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44. Biochem J. 2006 Feb 1;393(Pt 3):609-18. [2]Gil-Parrado S, et al. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem. 2002 Jul 26;277(30):27217-26. [3]Liu C,et al. Characterization of ionomycin as a calcium ionophore. J Biol Chem. 1978 Sep 10;253(17):5892-4. [4]Chatila T, et al. Mechanisms of T cell activation by the calcium ionophore ionomycin. J Immunol. 1989 Aug 15;143(4):1283-9. [5]Junsuke Uwada, et al. Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells. Cell Signal. 2019 Nov;63:109358.
Smiles	O=C(O)CC[C@@H](C)C[C@H](C)C[C@H](C)C(/C=C(O)/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@]([C@@H]2O[C@](C)([C@H](O)C)CC2)(C)O1)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	SQ23377
Available
Product Description	Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC)[1][2][3].
StorageTemperature	Solution, -20°C, 2 years
Shipping	Blue Ice
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	709.01
Clinical Information	No Development Reported
Solubility	DMSO : 100 mg/mL (ultrasonic)\|Ethanol : 100 mg/mL (ultrasonic)
Pathway	Anti-infection; Apoptosis; Epigenetics; Membrane Transporter/Ion Channel; Neuronal Signaling; TGF-beta/Smad
Manufacturers Product type	Natural Products

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 mg (14.1 mM x 100 ul in Ethanol)

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