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Infigratinib phosphate

Infigratinib phosphate

€69.00

Excl. VAT

Item no.	HY-13311A-10mg
Manufacturer	MedChem Express
CASRN	1310746-10-1
Amount	10 mg
Category	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Neural Adhesion Molecules Inhibitors & Compound Libraries Small Molecules By Organ Heart & Blood Cancer Uterine, Ovarian & Cervical Cancer Calcium Binding Protein Markers
Type	Inhibitors
Specific against	other
Purity	99.74
Formula	C26H34Cl2N7O7P
Citations	[1]Konecny GE, et al. Activity of the fibroblast growth factor receptor inhibitors dovitinib (TKI258) and NVP-BGJ398 in human endometrial cancer cells. Mol Cancer Ther. 2013 May;12(5):632-42. [2]Guagnano V, et al. Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-me thyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor T
Smiles	O=P(O)(O)O.ClC1=C(C(Cl)=C(C=C1OC)OC)NC(N(C2=CC(NC3=CC=C(C=C3)N4CCN(CC4)CC)=NC=N2)C)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BGJ-398 phosphate; NVP-BGJ398 (phosphate)
Available
Product Description	Infigratinib phosphate (BGJ-398 phosphate; NVP-BGJ398 phosphate) is a potent inhibitor of the FGFR family with IC50 of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	658.47
Clinical Information	Launched
Solubility	DMSO : ≥ 12.5 mg/mL
Isoform	FGFR1; FGFR2; FGFR3; FGFR4
Pathway	Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-13311A-10mg-safety-datasheet.pdf