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GSK2578215A

GSK2578215A

€87.00

Excl. VAT

Item no.	HY-13237-10mg
Manufacturer	MedChem Express
CASRN	1285515-21-0
Amount	10 mg
Category	Neuroscience Neuroinflammation Neural Mitochondrial Function Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.78
Formula	C24H18FN3O2
Citations	[1]Reith AD, et al. GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5625-9. [2]Saez-Atienzar S, et al. The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling. Cell Death Dis. 2014 Aug 14;5(8):e1368. [3]Chen L, et al. LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination-mediated DNA double strand break repair. Clin Transl Med. 2021 Mar;11(3):e341.
Smiles	FC1=NC=CC(C2=CC(C(NC3=CC=CN=C3)=O)=C(OCC4=CC=CC=C4)C=C2)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1285515-21-0
Available
Product Description	GSK2578215A is a potent and highly selective LRRK2 inhibitor, which exhibits IC50s of around 10 nM against both wild-type LRRK2 and the G2019S mutant.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
Molecular Weight	399.42
Clinical Information	No Development Reported
Solubility	DMSO : 50 mg/mL (ultrasonic)
Pathway	Autophagy
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-13237-10mg-safety-datasheet.pdf