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Sotuletinib

Sotuletinib

€97.00

Excl. VAT

Item no.	HY-12768-10mM
Manufacturer	MedChem Express
CASRN	953769-46-5
Amount	10 mM/1 mL
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Bone Cancer Uterine, Ovarian & Cervical Cancer
Type	Inhibitors
Specific against	other
Purity	99.78
Formula	C20H22N4O3S
Citations	[1]Pyonteck SM, et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med. 2013 Oct;19(10):1264-72. [2]Strachan DC, et al. CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells. Oncoimmunology. 2013 Dec 1;2(12):e26968.
Smiles	O=C(C1=NC=CC(OC2=CC=C3N=C(N[C@H]4[C@H](O)CCCC4)SC3=C2)=C1)NC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BLZ945
Available
Product Description	Sotuletinib (BLZ945) is a potent, selective and brain-penetrant CSF-1R (c-Fms) inhibitor with an IC50 of 1 nM, showing more than 1, 000-fold selectivity against its closest receptor tyrosine kinase homologs[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	398.48
Clinical Information	Phase 2
Solubility	DMSO : 83.33 mg/mL (ultrasonic)
Pathway	Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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HY-12768-10mM-safety-datasheet.pdf