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Vps34-IN-2

Vps34-IN-2

€1,869.00

Excl. VAT

Item no.	HY-12473-25mg
Manufacturer	MedChem Express
CASRN	1523404-29-6
Amount	25 mg
Category	Oncology By Cell Type Cell Biology Cell Status Autophagy Cardiovascular Research Myocardial Infarction Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.81
Formula	C18H25F3N4O3
Citations	[1]Jim Baggen, et al. Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2. Nat Genet. 2021 Mar 8. [2]Pasquier B, et al. Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors. J Med Chem. 2015 Jan 8;58(1):376-400.
Smiles	O=C1C=C(N2[C@H](C)COCC2)N=C3N(CC(C(C)C)=O)[C@H](C(F)(F)F)CCN31
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1523404-29-6
Available
Product Description	Vps34-IN-2 is a novel, potent and selective inhibitor of Vps34 with IC50s of 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively[1]. Vps34-IN-2 shows antiviral activity against SARS-CoV-2 (IC50 of 3.1 μM), HCoV-229E (IC50 of 0.7 μM) and HCoV-OC43[2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	402.41
Clinical Information	No Development Reported
Solubility	Ethanol : 50 mg/mL (ultrasonic)
Isoform	Vps34
Pathway	Anti-infection; PI3K/Akt/mTOR
Manufacturers Product type	Reference compound

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HY-12473-25mg-safety-datasheet.pdf