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INT-767

INT-767

€1,082.00

Excl. VAT

Item no.	HY-12434-10mg
Manufacturer	MedChem Express
CASRN	1000403-03-1
Amount	10 mg
Category	Metabolism Diabetes Cholesterol & Lipid Metabolism Inhibitors & Compound Libraries Small Molecules Other Lipid\Cholesterol Metabolism Modulators
Type	Inhibitors
Specific against	other
Purity	98.0
Formula	C25H43NaO6S
Citations	[1]Baghdasaryan A, et al. Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mousecholangiopathy model by promoting biliary HCO3- output. Hepatology. 2011 Oct;54(4):1303-1312. [2]Rizzo G, et al. Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor andTGR5 agonist. Mol Pharmacol. 2010 Oct;78(4):617-630.
Smiles	C[C@H](CCOS(=O)(O[Na])=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)[C@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1000403-03-1
Available
Product Description	INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively[1][2].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	494.66
Clinical Information	No Development Reported
Solubility	DMSO : ≥ 100 mg/mL\|H2O : 100 mg/mL (ultrasonic)
Pathway	Autophagy; GPCR/G Protein; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-12434-10mg-safety-datasheet.pdf