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Gilteritinib

Gilteritinib

€541.00

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Item no.	HY-12432-100mg
Manufacturer	MedChem Express
CASRN	1254053-43-4
Amount	100 mg
Category	Oncology Neuroscience Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Bone Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.69
Formula	C29H44N8O3
Citations	Biomed Pharmacother. 2023 Jun 29;165:115066. Blood Cancer J. 2022 Jan 11;12(1):5. Cancer Cell Int. 2020 Jun 17;20:250. Cancer Discov. 2023 Apr 3;CD-22-0411. Cancers. 2020 Aug 19;12(9):2341. Cancers. 2020 Jun 14;12(6):1574. Comput Biol Med. 2023 Dec 21, 107889. Department of Pharmacology & Toxicology. 2020 Jul. Front Pharmacol. 2021 Mar 8;12:644342. Haematologica. 2018 Nov;103(11):1862-1872. J Oncol. 21 Sep 2021. Mol Cancer Res. 2021 Oct 11. Mol Pharmacol. April 5, 2022. Mol Syst Biol. 2023 Dec 18. Research Square Preprint. 2023 Dec 6. Sci Adv. 2022 Sep 16;8(37):eabp9005. Sci Rep. 2021 Mar 11;11(1):5715. Science. 2017 Dec 1;358(6367):eaan4368. Separations. 2023 Apr 25, 10(5), 278. Target Oncol. 2022 Oct 6. Blood Cancer Discov. 2022 Mar 4;bloodcandisc.0163.2021. Eur J Med Chem. 2022 Jul 5;237:114356. [1]Mori M, et al. Gilteritinib, a FLT3/AXL inhibitor, shows antileukemic activity in mouse models of FLT3 mutated acute myeloid leukemia. Invest New Drugs. 2017 Oct;35(5):556-565. [2]ASP2215, a novel FLT3/AXL inhibitor: Preclinical evaluation in acute myeloid leukemia (AML). 2014 ASCO Annual Meeting.
Smiles	NC(C1=NC(CC)=C(NC2CCOCC2)N=C1NC3=CC(OC)=C(N4CCC(N5CCN(C)CC5)CC4)C=C3)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ASP2215
Available
Product Description	Gilteritinib (ASP2215) is a potent and ATP-competitive FLT3/AXL inhibitor with IC50s of 0.29 nM/0.73 nM, respectively.
StorageTemperature	4°C (Powder, stored under nitrogen)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	552.71
Clinical Information	Launched
Solubility	DMSO : 2 mg/mL (ultrasonic)\|Ethanol : 100 mg/mL (ultrasonic; adjust pH to 2 with HCl)
Pathway	Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-12432-100mg-safety-datasheet.pdf