K02288

€344.00

Excl. VAT

Item no.	HY-12278-50mg
Manufacturer	MedChem Express
CASRN	1431985-92-0
Amount	50 mg
Category	Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules Neurodegeneration Markers
Type	Inhibitors
Purity	99.73
Formula	C20H20N2O4
Citations	[1]Sanvitale CE, et al. A new class of small molecule inhibitor of BMP signaling. PLoS One. 2013 Apr 30;8(4):e62721. [2]Kerr G, et al. A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis. Angiogenesis. 2015 Apr;18(2):209-17.
Smiles	OC1=CC=CC(C2=CC(C3=CC(OC)=C(OC)C(OC)=C3)=C(N)N=C2)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1431985-92-0
Available
Product Description	K02288 is a potent bone morphogenetic protein (BMP) type I receptor inhibitor with IC50s of 1.8, 1.1, 6.4 nM for ALK1, ALK2 and ALK6, respectively. K02288 shows slightly weaker inhibition against ALK3 and ALK6 with IC50s of of 5-34 nM.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Molecular Weight	352.38
Clinical Information	No Development Reported
Solubility	DMSO : ≥ 58.6 mg/mL
Pathway	TGF-beta/Smad
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-12278-50mg-safety-datasheet.pdf