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MSI-1436 lactate

MSI-1436 lactate

€1,122.00

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Item no.	HY-12219A-5mg
Manufacturer	MedChem Express
CASRN	1309370-86-2
Amount	5 mg
Category	Oncology Neuroscience Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Brain Cancer Nervous System Cancer
Type	Inhibitors
Purity	99.67
Formula	C37H72N4O5S.7/2C3H6O3
Citations	[1]Lantz KA, et al. Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity (Silver Spring). 2010 Aug;18(8):1516-1523. [2]Qin Z, et al. Chronic stress induces anxiety via an amygdalar intracellular cascade that impairs endocannabinoid signaling. Neuron. 2015 Mar 18;85(6):1319-31. [3]Qin Z, et al. Functional properties of Claramine: a novel PTP1B inhibitor and mimetic compound. Biochem Biophys Res Commun. 2015 Feb 27;458(1):21-7.
Smiles	NCCCNCCCCNCCCN[C@@H]1C[C@@](C[C@@H](O)[C@]2([H])[C@]3([H])CC[C@@]4(C)[C@@]2([H])CC[C@@]4([C@H](C)CC[C@@H](OS(=O)(O)=O)C(C)C)[H])([H])[C@]3(C)CC1.O=C(O)C(C)O.[3.5]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Trodusquemine lactate; Aminosterol-1436 lactate
Available
Product Description	MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC50 of 1 μM, 200-fold preference over TCPTP (IC50 of 224 μM).
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Molecular Weight	1000.17
Clinical Information	Phase 1
Solubility	0.1 M HCL : 50 mg/mL (ultrasonic; adjust pH to 4 with HCl)\|DMSO : 54 mg/mL (ultrasonic; warming)
Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-12219A-5mg-safety-datasheet.pdf