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Prinomastat

Prinomastat

€369.00

Excl. VAT

Item no.	HY-12170-5mg
Manufacturer	MedChem Express
CASRN	192329-42-3
Amount	5 mg
Category	Oncology Food Safety Allergenes Neuroscience Neural Lineage Markers Neuroinflammation Molecular Targets for Neuroscience Neural Development Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer
Type	Inhibitors
Specific against	other
Purity	98.0
Formula	C18H21N3O5S2
Citations	Sci Adv. 2023 Jan 20;9(3):eadd3867. J Neuropathol Exp Neurol. 2022 Jun 3;nlac041. [1]Sørensen MD, et al. Cyclic phosphinamides and phosphonamides, novel series of potent matrix metalloproteinase inhibitors with antitumour activity. Bioorg Med Chem. 2003 Dec 1;11(24):5461-84. [2]Blavier L, et al. Stromelysin-1 (MMP-3) is a target and a regulator of Wnt1-induced epithelial-mesenchymal transition (EMT). Cancer Biol Ther. 2010 Jul 15;10(2):198-208. [3]Shalinsky DR, et al. Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials. Ann N Y Acad Sci. 1999 Jun 30;878:236-70. [4]Ozerdem U, et al. The effect of prinomastat (AG3340), a potent inhibitor of matrix metalloproteinases, on a subacute model of proliferative vitreoretinopathy. Curr Eye Res. 2000 Jun;20(6):447-53.
Smiles	O=C([C@@H]1N(S(=O)(C2=CC=C(OC3=CC=NC=C3)C=C2)=O)CCSC1(C)C)NO
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AG3340; KB-R9896
Available
Product Description	Prinomastat (AG3340) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC50s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9, respectively. Prinomastat inhibits MMP-2, MMP-3 and MMP-9 with Kis of 0.05 nM, 0.3 nM and 0.26 nM, respectively. Prinomastat crosses blood-brain barrier. Antitumor avtivity[1][2][3][4].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	423.51
Clinical Information	Phase 3
Solubility	DMSO : 2.5 mg/mL (ultrasonic; adjust pH to 4 with 1M HCl)\|H2O : < 0.1 mg/mL (ultrasonic)\|H2O : 2.5 mg/mL (ultrasonic; adjust pH to 3 with HCl)
Isoform	MMP-1; MMP-2; MMP-3; MMP-9
Pathway	Apoptosis; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-12170-5mg-safety-datasheet.pdf