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Pimasertib

Pimasertib

€303.00

Excl. VAT

Item no.	HY-12042-100mg
Manufacturer	MedChem Express
CASRN	1236699-92-5
Amount	100 mg
Category	Neuroscience Neural Lineage Markers Targets for Rodent Neurosciences Neural Signaling Inhibitors & Compound Libraries Small Molecules Oligodendrocyte Markers
Type	Inhibitors
Purity	99.88
Formula	C15H15FIN3O3
Citations	[1]Kim K, et al. Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo. Br J Haematol, 2010, 149(4), 537-549. [2]Yoon J, et al. MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy. Cancer Res, 2011, 71(2), 445-453. [3]Park SJ, et al. The MEK1/2 inhibitor AS703026 circumvents resistance to the BRAF inhibitor PLX4032 in human malignant melanoma cells. Am J Med Sci. 2013 Dec;346(6):494-8.
Smiles	FC1=C(C=CC(I)=C1)NC2=CN=CC=C2C(NC[C@@H](CO)O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AS703026; MSC1936369B
Available
Product Description	Pimasertib (AS703026) is a highly selective, ATP non-competitive allosteric orally available MEK1/2 inhibitor[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	431.20
Clinical Information	Phase 2
Solubility	DMSO : ≥ 100 mg/mL
Isoform	MEK1; MEK2
Pathway	MAPK/ERK Pathway
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-12042-100mg-safety-datasheet.pdf