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N-Desethyl Sunitinib

N-Desethyl Sunitinib

€162.00

Excl. VAT

Item no.	HY-10873-10mM
Manufacturer	MedChem Express
CASRN	356068-97-8
Amount	10 mM/1 mL
Category	Oncology Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer Heart & Blood Cancer Testicular & Prostate Cancer Bone Cancer
Type	Inhibitors
Specific against	other
Purity	99.63
Formula	C20H23FN4O2
Citations	[1]Sun L, et al. Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor r [2]Mendel DB, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Can [3]O'Farrell AM, et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood. 2003 May 1;101(9):3597-605. Epub 2003 Jan 16.
Smiles	O=C1NC2=CC=C(F)C=C2/C1=C/C3=C(C)C(C(NCCNCC)=O)=C(C)N3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	SU-12662
Available
Product Description	N-Desethyl Sunitinib (SU-12662) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	370.42
Clinical Information	No Development Reported
Solubility	DMSO : 6.25 mg/mL (ultrasonic; warming; heat to 60°C)
Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-10873-10mM-safety-datasheet.pdf