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Pemetrexed disodium

Pemetrexed disodium

€65.00

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Item no.	HY-10820A-50mg
Manufacturer	MedChem Express
CASRN	150399-23-8
Amount	50 mg
Category	Metabolism Cholesterol & Lipid Metabolism Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.99
Formula	C20H19N5Na2O6
Citations	Beilstein J Org Chem. 2017 Oct 25;13:2252-2263. Clin Transl Oncol. 2022 Jul 19. Faculty of the Graduate School of Biomedical Sciences. The University of Texas Southwestern Medical Center. Oct 1. 2015. J Mol Med (Berl). 2019 Aug;97(8):1183-1193. Mol Cell. 2019 Dec 5;76(5):838-851.e5. Odontology. 2020 Apr;108(2):300-311. Acta Pharmacol Sin. 2021 Jan;42(1):108-114. Br J Cancer. 2023 Jun 27. Cell Death Discov. 2022 Jul 5;8(1):307. Cell Rep Med. 2023 Jan 10;100911. Commun Biol. 2022 Jun 23;5(1):619. Int Immunopharmacol. 2023 Nov 3;125(Pt A):111158. J Clin Invest. 2021 Aug 2;131(15):e138022. J Control Release. 2022 Dec 9;353:490-506. Pharmacol Res Perspect. 2020 Apr;8(2):e00575. Research Square Print. September 27th, 2022. Theranostics. 2020 May 15;10(13):6048-6060. J Mol Med (Berl). 2019 Aug;97(8):1183-1193. [1]Shih C, et al. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. 1997 Mar 15;57(6):1116-23. [2]Anraku M, et al. Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignantmesothelioma. J Immunol. 2010 Jul 15;185(2):956-66.
Smiles	O=C1NC(N)=NC2=C1C(CCC3=CC=C(C=C3)C(N[C@@H](CCC(O[Na])=O)C(O[Na])=O)=O)=CN2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	LY231514 (disodium)
Available
Product Description	Pemetrexed disodium (LY231514 disodium) is an antifolate, the Kis of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively[1].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	471.37
Clinical Information	Launched
Solubility	H2O : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Pathway	Apoptosis; Autophagy; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-10820A-50mg-safety-datasheet.pdf