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Pemetrexed

Pemetrexed

€59.00

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Item no.	HY-10820-50mg
Manufacturer	MedChem Express
CASRN	137281-23-3
Amount	50 mg
Category	Metabolism Cholesterol & Lipid Metabolism Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.95
Formula	C20H21N5O6
Citations	Acta Pharmacol Sin. 2021 Jan;42(1):108-114. Br J Cancer. 2023 Jun 27. Cell Death Discov. 2022 Jul 5;8(1):307. Cell Rep Med. 2023 Jan 10;100911. Commun Biol. 2022 Jun 23;5(1):619. Int Immunopharmacol. 2023 Nov 3;125(Pt A):111158. J Clin Invest. 2021 Aug 2;131(15):e138022. J Control Release. 2022 Dec 9;353:490-506. Pharmacol Res Perspect. 2020 Apr;8(2):e00575. Research Square Print. September 27th, 2022. Theranostics. 2020 May 15;10(13):6048-6060. Beilstein J Org Chem. 2017 Oct 25;13:2252-2263. Clin Transl Oncol. 2022 Jul 19. Faculty of the Graduate School of Biomedical Sciences. The University of Texas Southwestern Medical Center. Oct 1. 2015. J Mol Med (Berl). 2019 Aug;97(8):1183-1193. Mol Cell. 2019 Dec 5;76(5):838-851.e5. Odontology. 2020 Apr;108(2):300-311. J Mol Med (Berl). 2019 Aug;97(8):1183-1193. [1]Anraku M, et al. Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignantmesothelioma. J Immunol. 2010 Jul 15;185(2):956-66. [2]Shih C, et al. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. 1997 Mar 15;57(6):1116-23.
Smiles	O=C1NC(N)=NC2=C1C(CCC3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C3)=CN2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	LY231514
Available
Product Description	Pemetrexed (LY231514) is an antifolate, the Ki values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	427.41
Clinical Information	Launched
Solubility	DMSO : 250 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Pathway	Autophagy; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-10820-50mg-safety-datasheet.pdf