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MK-3903

MK-3903

€144.00

Excl. VAT

Item no.	HY-107988-10mM
Manufacturer	MedChem Express
CASRN	1219737-12-8
Amount	10 mM/1 mL
Category	Neuroscience Metabolism Diabetes Cholesterol & Lipid Metabolism Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Inhibitors & Compound Libraries Small Molecules Other Lipid\Cholesterol Metabolism Modulators
Type	Inhibitors
Specific against	other
Purity	98.03
Formula	C27H19ClN2O3
Citations	[1]Lan P, Romero FA, et al. Hit-to-Lead Optimization and Discovery of 5-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase. J Med Chem. 2017 Nov 9;60(21):9040-9052.
Smiles	ClC1=CC2=C(NC(OC3=CC=C(C)C(C(O)=O)=C3)=N2)C=C1C(C=C4)=CC=C4C5=CC=CC=C5
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1219737-12-8
Available
Product Description	MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-sugar/lipid metabolism
Molecular Weight	454.90
Clinical Information	No Development Reported
Solubility	DMSO : ≥ 100 mg/mL
Isoform	AMPK
Pathway	Epigenetics; PI3K/Akt/mTOR
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-107988-10mM-safety-datasheet.pdf