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Luminespib

Luminespib

€91.00

Excl. VAT

Item no.	HY-10215-10mg
Manufacturer	MedChem Express
CASRN	747412-49-3
Amount	10 mg
Category	Oncology Neuroscience Neural Lineage Markers Neural Transcription Factors Aging & Neurological Disorders Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer Pancreatic Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.89
Formula	C26H31N3O5
Citations	[1]Eccles, Suzanne A., et al. NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis. Cancer Research (2008), 68(8), 2850-2860. [2]Best OG, et al. Heat shock protein-90 inhibitor, NVP-AUY922, is effective in combination with NSC 118218 against chronic lymphocytic leukemia cells cultured on CD40L-stromal layer and inhibits their activated/proliferative phenotype. Leuk Lymphoma. 2012 Jul 9. [3]Moser C, et al. Stoeltzing O.Targeting HSP90 by the novel inhibitor NVP-AUY922 reduces growth and angiogenesis of pancreatic cancer. Anticancer Res. 2012 Jul;32(7):2551-61.
Smiles	O=C(C1=NOC(C2=CC(C(C)C)=C(O)C=C2O)=C1C3=CC=C(CN4CCOCC4)C=C3)NCC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	VER-52296; AUY922; NVP-AUY922
Available
Product Description	Luminespib (VER-52296) is a potent HSP90 inhibitor with IC50s of 7.8 and 21 nM for HSP90α and HSP90β, respectively[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	465.54
Clinical Information	Phase 2
Solubility	DMSO : ≥ 62 mg/mL
Isoform	HSP90
Pathway	Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-10215-10mg-safety-datasheet.pdf