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Dasatinib hydrochloride

Dasatinib hydrochloride

€65.00

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Item no.	HY-10181A-100mg
Manufacturer	MedChem Express
CASRN	854001-07-3
Amount	100 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Heart & Blood Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	98.86
Formula	C22H27Cl2N7O2S
Citations	Front Pharmacol. 2023 Aug 29;14:1250383. J Hematol Oncol. 2018 Aug 29;11(1):109. PLoS Negl Trop Dis. 2019 Aug 20;13(8):e0007681. ACS Omega. October 26, 2022. ACS Pharmacol Transl Sci. 2023 May 2. Adv Funct Mater. 27 January 2022. Aging. 2020 Jun 25;12(12):11337-11348. Artif Cells Nanomed Biotechnol. 2023 Oct 5. Behav Brain Res. 2022 Dec 16;114260. Biochem Pharmacol. 2023 Jan 30. Bioconjug Chem. 2023 Jul 17. Biogerontology. 2022 Apr 25:1-15. Biol Pharm Bull. 2017;40(10):1747-1753. Biomaterials. 16 September 2022. Biomed Chromatogr. 2019 Dec;33(12):e4674. Biomed Pharmacother. 2023 Apr 12;162:114680. Biomolecules. 2022 Jun 11;12(6):819. bioRxiv. 2023 Dec 14. Br J Cancer. 2022 Nov 1. Breast Cancer Res Treat. 2020 Jan;179(2):337-347. Cancer Cell Int. 2021 Jun 5;21(1):291. Cancer Cell Int. 2023 Dec 16;23(1):323. Cancers (Basel). 2022 Mar 11;14(6):1451. Cell Biochem Funct. 2020 Jul;38(5):642-650. Cell Death Dis. 2021 Dec 3;12(12):1126. Cell Mol Gastroenterol Hepatol. 2022 Apr 2;14(1):75-99. Cell. 2021 Oct 28;184(22):5670-5685.e23. Cells. 2023 Dec 14, 12(24), 2836. Chem Biol Interact. 2021 Oct 27;109729. Chem Pharm Bull (Tokyo). 2017 Aug 1;65(8):768-775. Clin Sci. 2021 Jul 20;CS20210571. Diseases. 2023 Oct 23;11(4):147. Eur J Pharmacol. 2021 Feb 10;173944. Exp Cell Res. 2020 Aug 1;393(1):112054. Exp Eye Res. 2022 Aug 2;223:109207. FASEB J. 2024 Jan;38(1):e23355. Front Cell Dev Biol. 2021 Mar 16;9:618045. Front Microbiol. 2019 Aug 7;10:1816. Front Pharmacol. 2021 Mar 8;12:644342. Harvard Medical School LINCS LIBRARY Hum Exp Toxicol. 2023 Jan-Dec;42:9603271231188492. Int J Rheum Dis. 2023 Feb 21. iScience. 2023 Jul 21. J Anim Sci Biotechnol. 2021 May 10;12(1):63. J Cancer Res Clin Oncol. 2022 Nov 19. J Clin Invest. 2019 Mar 1;129(3):972-987. J Clin Invest. 2023 Feb 16;e162324. J Hematol Oncol. 2022 Apr 29;15(1):46. J Immunol Res. 2022 Apr 28;2022:6324326. J Immunother Cancer. 2020 Mar;8(1):e000111. J Med Chem. 2021 Mar 11;64(5):2725-2738. J Med Chem. 2021 Sep 21. J Pharm Anal. 2021 Jun 19. J Pineal Res. 2019 Sep;67(2):e12588. J Transl Med. 2022 Jun 21;20(1):278. Kawasaki Medical Journal. 43(2)：63-78，2017. Leukemia. 2012 Oct;26(10):2233-44. Leukemia. 2020 Jun;34(6):1524-1539. Med Oncol. 2022 Dec 16;40(1):49. Mol Ther. 2023 Feb 28;S1525-0016(23)00116-8. Molecules. 2018 Mar 23;23(4). pii: E736. Nat Biomed Eng. 2018 Aug;2(8):578-588. Nat Cell Biol. 2023 Mar;25(3):493-507. Nat Commun. 2020 Apr 14;11(1):1790. Nat Commun. 2020 Apr 20;11(1):1913. Oncogenesis. 2022 Apr 11;11(1):15. Oncotarget. 2016 Aug 30;7(35):56241-56252. Patent. US10174018B2. Patent. US20180099959A1. Patent. US20180099960A1. Patent. US20180099961A1. Patent. US20180263995A1. PLoS One. 2013;8(2):e56473. PLoS One. 2018 Jun 14;13(6):e0199208. Purdue University. Department of Chemistry. Sci Transl Med. 2018 Jul 18;10(450):eaaq1093. Stem Cell Reports. 2017 Dec 12;9(6):1948-1960. Target Oncol. 2020 Oct;15(5):659-671. Technical University of Munich. 24.01.2018. Int J Pharm Res Allied Sci. 2023 Mar;13(1):139-148. [1]Lombardo LJ, et al. Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem. 2004 Dec 30;47(27):6658-61.
Smiles	O=C(C1=CN=C(S1)NC2=NC(C)=NC(N3CCN(CC3)CCO)=C2)NC4=C(C=CC=C4Cl)C.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BMS-354825 (hydrochloride)
Available
Product Description	Dasatinib (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib hydrochloride inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively[1]. Dasatinib hydrochloride also induces apoptosis and autophagy.
StorageTemperature	4°C (Powder, stored under nitrogen)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	524.47
Clinical Information	Launched
Solubility	DMSO : 15 mg/mL (ultrasonic; warming)\|H2O : 10 mg/mL (ultrasonic)
Isoform	Bcr-Abl
Pathway	Apoptosis; Autophagy; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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HY-10181A-100mg-safety-datasheet.pdf