TM5441

€846.00

Excl. VAT

Item no.	HY-101761-100mg
Manufacturer	MedChem Express
CASRN	1190221-43-2
Amount	100 mg
Category	Oncology Food Safety Proteins Inhibitors & Compound Libraries Small Molecules By Organ Breast Cancer
Type	Inhibitors
Purity	98.32
Formula	C21H17ClN2O6
Citations	[1]Placencio VR, et al. Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1 Elicit Anti-Tumorigenic and Anti-Angiogenic Activity. PLoS One. 2015 Jul 24;10(7):e0133786. [2]Jeong BY, et al. Novel Plasminogen Activator Inhibitor-1 Inhibitors Prevent Diabetic Kidney Injury in a Mouse Model. PLoS One. 2016 Jun 3;11(6):e0157012.
Smiles	ClC1=CC=C(NC(COCC(NC2=CC=CC(C3=COC=C3)=C2)=O)=O)C(C(O)=O)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1190221-43-2
Available
Product Description	TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC50 values between 13.9 and 51.1 μM and induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	428.82
Clinical Information	No Development Reported
Solubility	DMSO : 100 mg/mL (ultrasonic)
Pathway	Apoptosis; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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HY-101761-100mg-safety-datasheet.pdf