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Nilotinib monohydrochloride monohydrate

Nilotinib monohydrochloride monohydrate

€65.00

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Item no.	HY-10159A-10mM
Manufacturer	MedChem Express
CASRN	923288-90-8
Amount	10 mM/1 mL
Category	Oncology Metabolism Diabetes Glucose Homeostasis Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Heart & Blood Cancer Gastric Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.97
Formula	C28H25ClF3N7O2
Citations	bioRxiv. January 25, 2022. Drug Metab Pharmacokinet. 2020 Feb;35(1):102-110. ACS Chem Biol. 2016 Apr 15;11(4):992-1000. Biomaterials. 16 September 2022. Biomed Chromatogr. 2019 Dec;33(12):e4674. Biomolecules. 2022 Jun 11;12(6):819. Br J Cancer. 2021 Nov 24. Breast Cancer Res. 2023 May 5;25(1):51. Cancer Biol Ther. 2019;20(6):877-885. Cancer Med. 2016 Nov;5(11):3223-3234. Cell Death Dis. 2021 Sep 25;12(10):875. Cell Syst. 2018 Apr 25;6(4):424-443.e7. Diseases. 2023 Oct 23;11(4):147. Eur J Pharmacol. 2021 Feb 10;173944. Glia. 2022 Feb 13. Harvard Medical School LINCS LIBRARY Int J Mass Spectrom. 442 (2019) 44-50. J Pharm Sci. 2017 Sep;106(9):2632-2641. Leuk Lymphoma. 2015;56(8):2416-23. Oncotarget. 2018 Apr 24;9(31):22158-22183. Patent. US20190084960A1 Patent. US20210299273A1. Sci Transl Med. 2018 Jul 18;10(450):eaaq1093. Stem Cell Reports. 2019 May 14;12(5):996-1006. Target Oncol. 2020 Oct;15(5):659-671. Technical University of Munich. 24.01.2018. Toxicol Lett. 2022 Jun 6;S0378-4274(22)00117-5. Xenobiotica. 2018 Oct;48(10):1059-1071. [1]Dervis Hakim G, et al. Mucosal healing effect of nilotinib in indomethacin-induced enterocolitis: A rat model. World J Gastroenterol. 2015 Nov 28;21(44):12576-85. [2]Weisberg E, et al. Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias. Blood. 2007 Mar 1;109(5):2112-20. [3]Sako H, et al. Antitumor effect of the tyrosine kinase inhibitor Nilotinib on gastrointestinal stromal tumor (GIST) and Imatinib-resistant GIST cells. PLoS One. 2014 Sep 15;9(9):e107613.
Smiles	O=C(NC1=CC(C(F)(F)F)=CC(N2C=NC(C)=C2)=C1)C3=CC=C(C)C(NC4=NC=CC(C5=CC=CN=C5)=N4)=C3.[H]Cl.O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	AMN107 (monohydrochloride monohydrate)
Available
Product Description	Nilotinib monohydrochloride monohydrate is a second generation tyrosine kinase inhibitor (TKI), is significantly potent against BCR-ABL, and is active against many BCR-ABL mutants.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	583.99
Clinical Information	Launched
Solubility	DMSO : 33.33 mg/mL (ultrasonic)\|H2O : 0.1 mg/mL (ultrasonic)
Pathway	Autophagy; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-10159A-10mM-safety-datasheet.pdf