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Y-33075

Y-33075

€1,286.00

Excl. VAT

Item no.	HY-10067-50mg
Manufacturer	MedChem Express
CASRN	199433-58-4
Amount	50 mg
Category	Oncology Food Safety Histamines Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer
Type	Inhibitors
Specific against	other
Purity	99.19
Formula	C16H16N4O
Citations	J Cell Physiol. 2021 Jun 27. Patent. US20170349879A1. PLoS One. 2023 Jan 31;18(1):e0270288. Stem Cell Rep. 2020 Jan 14;14(1):49-59. Adv Sci (Weinh). 2022 Mar 3;e2104682. Cell. 2018 Jul 26;174(3):636-648.e18. Harvard Medical School LINCS LIBRARY J Adv Res. 2023 Oct 6:S2090-1232(23)00299-0. Nat Commun. 2020 Jan 3;11(1):88. Neurotox Res. 2013 Apr;23(3):238-48. Science. 2017 Dec 1;358(6367):eaan4368. [1]Hideki Tokushige, et al. Effects of Topical Administration of Y-39983, a Selective Rho-Associated Protein Kinase Inhibitor, on Ocular Tissues in Rabbits and Monkeys Invest. Ophthalmol. Vis. Sci. July 2007 vol. 48no. 7 3216-3222 [2]Tokushige H, et al. Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats. Curr Eye Res. 2011 Oct;36(10):964-70. [3]Watabe H, et al. Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries.Jpn J Ophthalmol. 2011 Jul;55(4):411-7. Epub 2011 Jun 11.
Smiles	O=C(NC1=C2C(NC=C2)=NC=C1)C3=CC=C(C=C3)[C@H](N)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Y-39983 (free base)
Available
Product Description	Y-33075 is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	280.32
Clinical Information	No Development Reported
Solubility	DMSO : 50 mg/mL (ultrasonic; warming)\|H2O : 1 mg/mL (ultrasonic; heat to 60°C)
Isoform	ROCK
Pathway	Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-10067-50mg-safety-datasheet.pdf