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Peretinoin

Peretinoin

€108.00

Excl. VAT

Item no.	HY-100008-10mM
Manufacturer	MedChem Express
CASRN	81485-25-8
Amount	10 mM/1 mL
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Hepatic Cancer
Type	Inhibitors
Specific against	other
Purity	99.79
Formula	C20H30O2
Citations	[1]Funaki M, et al. Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo. Sci Rep. 2017 Dec 5;7(1):16978. [2]Okada H, et al. Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet. Oncotarget. 2017 Jun 20;8(25):39978-39993. [3]Honda M, et al. Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma. BMC Cancer. 2013 Apr 15;13:191.
Smiles	C/C(C)=C/CC/C(C)=C/CC/C(C)=C/C=C/C(C)=C/C(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	NIK333
Available
Product Description	Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1[1]. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression[2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM[3].
StorageTemperature	-20°C (Powder, protect from light, stored under nitrogen)
Shipping	Blue Ice
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	302.45
Clinical Information	Launched
Solubility	DMSO : 50 mg/mL (ultrasonic)
Pathway	Anti-infection; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-100008-10mM-safety-datasheet.pdf