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Z-WEHD-FMK

Z-WEHD-FMK

€207.00

Excl. VAT

Item no.	HY-P0111-5mg
Manufacturer	MedChem Express
CASRN	210345-00-9
Amount	5 mg
Category	Peptides & Proteins Peptides
Type	Peptides
Specific against	other
Purity	98.0
Formula	C37H42FN7O10
Citations	[1]Kamada S, et al. Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases.Cell Death Differ. 1997 Aug;4(6):473-8. [2]Yang D, et al. Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish.Nat Commun. 2018 Aug 3;9(1):3052. [3]Ferko MA, et al. Effects of metal ions on caspase-1 activation and interleukin-1β release in murine bone marrow-derived macrophages.PLoS One. 2018 Aug 23;13(8):e0199936. [4]Newman ZL, et al. CA-074Me protection against anthrax lethal toxin.Infect Immun. 2009 Oct;77(10):4327-36.
Smiles	O=C(N[C@@H](CCC(OC)=O)C(N[C@H](C(N[C@H](C(CF)=O)CC(OC)=O)=O)CC1=CN=CN1)=O)[C@@H](NC(OCC2=CC=CC=C2)=O)CC3=CNC4=C3C=CC=C4
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Z-WE(OMe)HD(OMe)-FMK
Available
Product Description	Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis[1][2][4].
StorageTemperature	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	Cancer-Kinase/protease
Molecular Weight	763.77
Clinical Information	No Development Reported
Solubility	DMSO : 100 mg/mL (ultrasonic)
Isoform	Caspase 1; Cathepsin B
Pathway	Apoptosis; Metabolic Enzyme/Protease
Manufacturers Product type	Peptides

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

Listprice: €207.00

Price: €207.00

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