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Darifenacin (hydrobromide)

Darifenacin (hydrobromide)

€25.00

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Item no.	HY-A0012-5mg
Manufacturer	MedChem Express
CASRN	133099-07-7
Amount	5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.82
Formula	C28H31BrN2O2
Citations	ACS Omega. 2020 Oct 12;5(41):26551-26561. Eur J Pharmacol. 2011 Aug 1;663(1-3):74-9. Br J Pharmacol. 2015 Dec;172(23):5619-33. Oncotarget. 2016 Apr 5;7(14):18085-94. Sci Rep. 2017 Jan 19;7:40802. [1]Hegde SS, et al. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol, 1997, 120(8), 1409-1418. [2]Miller DW, et al. Evaluation of drug efflux transporter liabilities of darifenacin in cell culture models of the blood-brain and blood-ocular barriers. Neurourol Urodyn, 2011, 30(8), 1633-1638. [3]Iijima K, et al. Effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve. Eur Urol, 2007, 52(3), 842-847.
Smiles	O=C(C(C1=CC=CC=C1)([C@@H]2CCN(CCC3=CC4=C(OCC4)C=C3)C2)C5=CC=CC=C5)N.Br
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	UK-88525 (hydrobromide)
Available
Product Description	Darifenacin hydrobromide (UK-88525 hydrobromide) is a selective M3 muscarinic receptor antagonist with a pKi of 8.9.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	507.46
Clinical Information	Launched
Solubility	DMSO : 33.33 mg/mL (ultrasonic)
Isoform	mAChR3
Pathway	GPCR/G Protein; Neuronal Signaling
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 5 mg

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