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Atazanavir

Atazanavir

€49.00

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Item no.	HY-17367-5mg
Manufacturer	MedChem Express
CASRN	198904-31-3
Amount	5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.23
Formula	C38H52N6O7
Citations	Aging Cell. 2022 Dec 20;e13750. Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00872-20. Faculty of Pharmacy in Hradec Králové Department of Pharmacological and Toxicology. University of Oxford. 2019 Jul. Int J Antimicrob Agents. 2019 Dec;54(6):814-819. PLoS Biol. 2020 Jan 16;18(1):e3000599. Research Square Print. 2022 May. bioRxiv. 2020 Apr. Curr Protoc. 2021 Feb;1(2):e32. Nat Commun. 2020 Sep 4;11(1):4417. Signal Transduct Target Ther. 2021 May 29;6(1):212. [1]Havlir DV, et al. Atazanavir: new option for treatment of HIV infection. Clin Infect Dis. 2004 Jun 1;38(11):1599-604. [2]Wood R. Atazanavir: its role in HIV treatment. Expert Rev Anti Infect Ther. 2008 Dec;6(6):785-96. [3]Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212.
Smiles	O=C(OC)N[C@@H](C(C)(C)C)C(NN(CC1=CC=C(C2=NC=CC=C2)C=C1)C[C@H](O)[C@H](CC3=CC=CC=C3)NC([C@H](C(C)(C)C)NC(OC)=O)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BMS-232632
Available
Product Description	Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
Manufacturers Applications	COVID-19-anti-virus
Molecular Weight	704.86
Clinical Information	Launched
Solubility	DMSO : 83.33 mg/mL (ultrasonic)
Isoform	CYP3; HIV-1
Pathway	Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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