NOX2-IN-2

Item no.	HY-156425
Manufacturer	MedChem Express
CASRN	2648709-79-7
Amount	1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Formula	C25H25N7O3
Citations	[1]Jie Zang, et al.Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors. J Med Chem. 2023 Oct 19.
Smiles	NC1=NC2=CC=C(C=C2C=C1)OCC3=CN(N=N3)CCOCCOC4=CC=C5N=C(C=CC5=C4)N
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	NOX2-IN-2 (compound 33) is a potent NOX2 inhibitor targeting the p47phox-p22phox protein-protein interaction with a Ki of 0.24 μM. NOX2-IN-2 inhibits ROS production derived from NOX2 in cells[1].
Shipping	Room temperature
Molecular Weight	471.51
Clinical Information	No Development Reported
Solubility	10 mM in DMSO
Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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