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Diclofenac

Diclofenac

€49.00

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Item no.	HY-15036-500mg
Manufacturer	MedChem Express
CASRN	15307-86-5
Amount	500 mg
Category	Cardiovascular Research Thrombosis & Hemostasis Atherosclerosis Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.98
Formula	C14H11Cl2NO2
Citations	Biotechnol Bioeng. 2021 Sep 3. Chem-Biol Interact. 2021, 109425. Chemosphere. 2019 Jun;225:378-387. Eur J Drug Metab Pharmacokinet. 2022 Jun 22. Institute of Chemistry, Federal University of Rio Grande do Sul (UFRGS). 2017 Nov. Int J Mol Sci. 2022, 23(20), 12066. J Hazard Mater. 2015 May 30;289:18-27. J Pharmaceut Biomed. 2021, 114105. J Phys Chem Solids. 2017 October;109:117-123. Biotechnol Bioeng. 2021 Sep 3. Biotechnol Bioeng. 2021 Sep 3. Phys Chem Chem Phys. 2016 Jan 21;18(3):1526-36. Toxicol Mech Methods. 2019 Nov;29(9):654-664. Pharm Res. 2022 Aug 24. [1]Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [2]Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80. [3]Chiho Kudo, et al. Diclofenac Inhibits Proliferation and Differentiation of Neural Stem Cells. Biochem Pharmacol. 2003 Jul 15;66(2):289-95.
Smiles	O=C(O)CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	15307-86-5
Available
Product Description	Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
Molecular Weight	296.15
Clinical Information	Launched
Solubility	DMSO : 125 mg/mL (ultrasonic)
Isoform	COX-1; COX-2
Pathway	Apoptosis; Immunology/Inflammation
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-15036-500mg-safety-datasheet.pdf