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(rel)-ML-SI3

(rel)-ML-SI3

€148.00

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Item no.	HY-139426A-10mg
Manufacturer	MedChem Express
CASRN	2108567-79-7
Amount	10 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.81
Formula	C23H31N3O3S
Citations	[1]Leser C, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021 Jan 15;210:112966. [2]Rühl P, et al. Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors. Sci Rep. 2021 Apr 15;11(1):8313. [Content Brief] [3]Xing Y, et al. Blunting TRPML1 channels protects myocardial ischemia/reperfusion injury by restoring impaired cardiomyocyte autophagy. Basic Res Cardiol. 2022 Apr 7;117(1):20. [Content Brief]
Smiles	O=S(N[C@H]1[C@H](N2CCN(C3=C(C=CC=C3)OC)CC2)CCCC1)(C4=CC=CC=C4)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	trans-ML-SI3
Available
Product Description	(rel)-ML-SI3 is the isomer of ML-SI3 (HY-139426). ML-SI3 is a TRPML Channel Inhibitor. ML-SI3 blocks TRPML1 and TRPML2 with IC50s of 4.7 μM and 1.7 μM, respectively. ML-SI3 prevents lysosomal calcium efflux and blocks downstream TRPML1-mediated induction of autophagy[1][2].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	429.58
Clinical Information	No Development Reported
Solubility	DMSO : 50 mg/mL (ultrasonic)
Isoform	TRPML
Pathway	Autophagy; Membrane Transporter/Ion Channel; Neuronal Signaling
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mg

Listprice: €148.00

Price: €148.00

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