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CCR4 antagonist 3 hydrochloride

CCR4 antagonist 3 hydrochloride

€9,052.00

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Item no.	HY-131349A-100mg
Manufacturer	MedChem Express
CASRN	2174938-71-5
Amount	100 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Small Molecules
Specific against	other
Purity	98.59
Formula	C24H27Cl2N7O.xHCl
Citations	[1]Omar Robles, et al. Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as Single Agent and in Combination with Checkpoint Inhibitors. J Med Chem. 2020 Jul 15.
Smiles	[H][C@@]1(CCCN(C1)CCO)C2CN(C2)C3=CN=C(C4=N3)C(C#N)=NN4[C@H](C)C5=CC=C(C=C5Cl)Cl.[H]Cl.[x]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	CCR4-351 hydrochloride is an orally active, potent and selective CCR4 antagonist. CCR4-351 hydrochloride, featuring a novel piperidinyl-azetidine motif, has IC50s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4-351 hydrochloride has antitumor activity[1].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-protein/nucleotide metabolism
Molecular Weight	N/A
Clinical Information	No Development Reported
Solubility	DMSO : 170 mg/mL (ultrasonic)
Isoform	CCR4
Pathway	GPCR/G Protein; Immunology/Inflammation
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 mg

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