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K-Ras ligand-Linker Conjugate 5

K-Ras ligand-Linker Conjugate 5

€974.00

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Item no.	HY-130823-10mM
Manufacturer	MedChem Express
CASRN	2378261-85-7
Amount	10 mM/1 mL
Category	Oncology By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Cell Biology Adenocarcinoma Cytoskeleton Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Colorectal Cancer small GTPases Ras Subfamily
Type	Inhibitors
Specific against	other
Purity	96.96
Formula	C42H59N7O8
Citations	[1]CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.
Smiles	O=C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)C[C@H](OCCOCCOCCOCCO)C6)=N2)CC1)OC(C)(C)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2378261-85-7
Available
Product Description	K-Ras ligand-Linker Conjugate 5 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 5 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].
StorageTemperature	-20°C (Powder, stored under nitrogen)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	789.96
Clinical Information	No Development Reported
Solubility	DMSO : ≥ 100 mg/mL
Pathway	PROTAC
Manufacturers Product type	Reference compound

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HY-130823-10mM-safety-datasheet.pdf