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KAG-308

KAG-308

€8,560.00

Excl. VAT

Item no.	HY-128686-50mg
Manufacturer	MedChem Express
CASRN	1215192-68-9
Amount	50 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.88
Formula	C24H30F2N4O3
Citations	[1]Watanabe Y, et al. KAG-308, a newly-identified EP4-selective agonist shows efficacy for treating ulcerative colitis and can bring about lower risk of colorectal carcinogenesis by oral administration. Eur J Pharmacol. 2015 May 5;754:179-89.
Smiles	O[C@H](C1)[C@H](/C=C/[C@@H](O)[C@@H](C2=CC=CC(C)=C2)C)[C@](C/3(F)F)([H])[C@@]1([H])OC3=C/CCCC4=NN=NN4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1215192-68-9
Similar products	1215192-68-9
Available
Product Description	KAG-308 is a potent selective and orally active agonist of EP4 receptor (a prostaglandin E2 receptor subtype), suppresses colitis and promotes histological mucosal healing, potently inhibits TNF-α production. KAG-308 shows a Ki and an EC50 of 2.57 nM and 17 nM for human EP4 receptor, respectively, more selective over EP1, EP2, EP3 and IP receptor[1].
StorageTemperature	-20°C (Powder, stored under nitrogen)
Shipping	Blue Ice
Manufacturers Applications	COVID-19-immunoregulation
Molecular Weight	460.52
Clinical Information	No Development Reported
Solubility	\|DMSO : 80 mg/mL (ultrasonic)
Isoform	EP
Pathway	GPCR/G Protein
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 mg

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