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GS-443902 trisodium

GS-443902 trisodium

€2,902.00

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Item no.	HY-126303C-10mg
Manufacturer	MedChem Express
CASRN	1355050-21-3
Amount	10 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.98
Formula	C12H13N5Na3O13P3
Dry ice	Yes
Citations	Nat Commun. 2021 Oct 4;12(1):5811. Acta Pharm Sin B. 2021 Mar 22. Cell. 2022 Nov 10;185(23):4347-4360.e17. Chem Biol Interact. 2021 Apr 19;109480. Current Research in Pharmacology and Drug Discovery. 2021, 100045. Int J Mol Sci. 2022, 23(15), 8302. Research Square Preprint. 2022 May. [1]Warren TK, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016 Mar 17;531(7594):381-5. [2]Siegel D, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. Med Chem. 2017 Mar 9;60(5):1648-1661. [3]Cho A, et al. Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2705-7.
Smiles	O=P(OP(O)(O[Na])=O)(O[Na])OP(OC[C@@H](O1)[C@@H](O)[C@@H](O)[C@]1(C#N)C2=CC=C3N2N=CN=C3N)(O[Na])=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	GS-441524 triphosphate (trisodium); Remdesivir metabolite (trisodium)
Similar products	1355050-21-3
Available
Product Description	GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734)[1][2].
StorageTemperature	-80°C, protect from light, stored under nitrogen
Shipping	Dry Ice
Manufacturers Applications	COVID-19-anti-virus
Molecular Weight	597.15
Clinical Information	No Development Reported
Solubility	H2O : 33.33 mg/mL (ultrasonic)
Pathway	Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mg

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