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(R)-OP-1074

(R)-OP-1074

€2,637.00

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Item no.	HY-125263B-25mg
Manufacturer	MedChem Express
CASRN	1443752-77-9
Amount	25 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.24
Formula	C29H31NO4
Citations	[1]Fanning SW, et al. Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity.Nat Commun. 2018 Jun 18;9(1):2368.
Smiles	OC1=CC=C2C(C)=C(C3=CC=C(O)C=C3)[C@@H](C4=CC=C(OCCN5C[C@H](C)CC5)C=C4)OC2=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	(R)-OP-1074 is the inactive isomer of OP-1074 (HY-125263), and can be used as an experimental control. OP-1074 is a pure antiestrogen and a selective ER degrader (PA-SERD), shows specific antiestrogenic activity for ERα and ERβ, inhibits 17β-estradiol (E2)-stimulated transcriptional activity with IC50 of 1.6 and 3.2?nM, respectively[1].
StorageTemperature	-20°C (Powder, stored under nitrogen, away from moisture)
Shipping	Blue Ice
Molecular Weight	457.56
Clinical Information	No Development Reported
Solubility	10 mM in DMSO
Pathway	Others
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25 mg

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