PI-828

€236.00

Excl. VAT

Item no.	HY-108606-5mg
Manufacturer	MedChem Express
CASRN	942289-87-4
Amount	5 mg
Category	Cardiovascular Research Thrombosis & Hemostasis Heart Failure Myocardial Infarction Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Purity	99.09
Formula	C19H18N2O3
Citations	[1]Gharbi SI, et al. Exploring the specificity of the PI3K family inhibitor LY294002. Biochem J. 2007 May 15;404(1):15-21. [2]Zellefrow CD, et al. Identification of druggable targets for radiation mitigation using a small interfering RNA screening assay. Radiat Res. 2012 Sep;178(3):150-9. [3]Kulkarni AA, et al. Supramolecular nanoparticles that target phosphoinositide-3-kinase overcome insulin resistance and exert pronounced antitumor efficacy. Cancer Res. 2013 Dec 1;73(23):6987-97.
Smiles	O=C1C=C(N2CCOCC2)OC3=C(C4=CC=C(N)C=C4)C=CC=C13
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	942289-87-4
Available
Product Description	PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC50s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
Molecular Weight	322.36
Clinical Information	No Development Reported
Solubility	DMSO : ≥ 12.5 mg/mL
Isoform	CK2; PI3Kα
Pathway	Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt
Manufacturers Product type	Reference compound

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HY-108606-5mg-safety-datasheet.pdf