CD10


Item no.	20-783-70664
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Antibodies Flow Cytometry Immunohistochemistry Immunoprecipitation Western Blot Primary Antibodies By Organ Renal Cancer
Type	Antibody
Applications	WB, FC, IP, IHC
Clone	SN5c
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-320383
Similar products	20-783-70664
Available
Genway ID:	GWB-320383
Specificity:	CD10NCBI
Gene ID:	4311
Specificity:	CD10
Clone:	SN5c
Immunogen:	Partially purified cell membrane antigens from fresh leukemia cells.
Fusion Partner:	Spleen cells from immunised BALB/c mice were fused with cells of the mouse PS/NS1/1-Ag4-1 myeloma cell line.
Specificity Note:	This product recognises the human CD10 cell surface antigen a 100kD glycoprotein expressed by acute lymphoblastic leukaemia cells and by peripheral blood granulocytes. CD10 is also known as the Common Acute Lymphoblastic Leukaemia Antigen (CALLA).
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:	Flow Cytometry - 1/100 - 1/200
Function:	Thermolysin-like specificity but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Involved in the degradation of atrial natriuretic factor (ANF).
Catalytic Activity:	Preferential cleavage of polypeptides between hydrophobic residues particularly with Phe or Tyr at P1\' . Cofactor: Binds 1 zinc ion per subunit.
Enzyme Regulation:	Inhibited in a dose dependent manner by opiorphin.
Subcellular Location:	Membrane; Single-pass type II membrane protein.
Disease:	Important cell surface marker in the diagnostic of human acute lymphocytic leukemia.
Similarity:	Belongs to the peptidase M13 family [view classification]. 1. Matsuzaki. H. et al. (1987) Unique epitopes of common acute lymphoblastic leukemia antigen detected by new monoclonal antibodies. 2. Biddle. W. C. et al. (1989) in vitro and in vivo cytotoxic activity of anti-human leukemia monoclonal antibodies SN5c and SN6 daunorubicin conjugates.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 0.1 mg

available

Delivery expected until 9/11/2025

Compare

Add to wishlist

Get an offer

Request delivery time