INTERLEUKIN 10

GWB-31B7C8

The antibody can be used for neutralisation of the biological activity of mouse IL-10. Furthermore the antibody is useful as detection antibody in ELISA and for immunoprecipitation. The anti-mouse interleukin 10 (IL-10) antibody neutralizes the biological activity of mouse IL-10. It does not cross-react with human IL-10. Mouse interleukin 10 (IL-10) is a multifunctional 30-40 kDa cytokine which is produced by TH2 mouse T Helper cell clones and which inhibits the synthesis of several cytokines by TH1 cells. Interleukin 10 was for this reason originally known as the Cytokine Synthesis Inhibitory Factor (CSIF). Interleukin 10 has activities which involve a wide variety of cell types. These activities include inhibition of macrophage cytokine synthesis; inhibition of antigen presentation (selective for TH1 cells); enhancement of B-cell survival; enhancement of MHC class II expression; contribution to the overall function of TH2 cells. Mouse IL-10 has been shown to exhibit extensive sequence similarity to human IL-10 and to an open reading frame in the Epstein-Barr virus genome BLRF-1. In contrast to human IL-10 which is active on mouse cells. mouse IL-10 is not active in human cells. Given the aforementioned range of effects of IL-10 and its potential anti-inflammatory properties. antibodies capable of blocking the biological activity are clearly essential in the study of these effects.

Homodimer (By similarity).

Belongs to the IL-10 family. [1] Lee C. W. Rao V. P. Rogers A. B. Ge Z. Erdman S. E. Whary M. T. and Fox J. G. Wild-type and interleukin-10-deficient regulatory T cells reduce effector T-cell-mediated gastroduodenitis in Rag2-/- mice but only wild-type regulatory T cells suppress Helicobacter pylori gastritis[2] Chang H. D. Helbig C. Tykocinski L. Kreher S. Koeck J. Niesner U. and Radbruch A. Expression of IL-10 in Th memory lymphocytes is conditional on IL-12 or IL-4 unless the IL-10 gene is imprinted by GATA-3[3] Shi M. Q. Wei G. J. and Tabel H. et al. Trypanosoma congolense infections: MHC class II-restricted immune responses mediate either protection or disease depending on IL-10 function[4] Shkoda A. Ruiz P. A. Daniel H. Kim S. C. Rogler G. Sartor R. B. and Haller D. Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammation[5] Evans K. E. and Fox S. W. et al. Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleus[6] Moore K. W. Vieira P. Fiorentino D. F. Trounstine M. L. Khan T. A. Mosmann T. R. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. [7] Kim J. M. Brannan C. I. Copeland N. G. Jenkins N. A. Khan T. A. Moore K. W. Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes. [8] Windsor W. T. Syto R. Tsarbopoulos A. Zhang R. Durkin J. Baldwin S. Paliwal S. Mui P. W. Pramanik B. Trotta P. P. et al. Disulfide bond assignments and secondary structure analysis of human and murine interleukin 10.