Interleukin-8 receptor type B

2nd extracellular domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (2 - 5 ug/ml) (Optimal dilution to be determined by the researcher) Summary: The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA) a protein with melanoma growth stimulating activity and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This protein IL8RA a gene encoding another high affinity IL8 receptor as well as IL8RBP a pseudogene of IL8RB form a gene cluster in a region mapped to chromosome 2q33-q36. [1] Omari K. M. John G. Lango R. and Raine C. S. et al. Role for CXCR2 and CXCL1 on glia in multiple sclerosis[2] Pereira-da-Silva G. Moreno A. N. Marques F. Oliver C. Celia Jamur M. Panunto-Castelo A. and Roque-Barreira M. C. Neutrophil activation induced by the lectin KM+ involves binding to CXCR2[3] Belperio J. A. Keane M. P. Burdick M. D. Gomperts B. N. Xue Y. Y. Hong K. Mestas J. Zisman D. Ardehali A. Saggar R. Lynch J. P. et al. CXCR2/CXCR2 ligand biology during lung transplant ischemia-reperfusion injury[4] Wilson S. Wilkinson G. and Milligan G. et al. The CXCR1 and CXCR2 receptors form constitutive homo- and heterodimers selectively and with equal apparent affinities[5] Zhang W. Stoehlmacher J. Park D. J. Yang D. Borchard E. Gil J. Tsao-Wei D. D. Yun J. Gordon M. Press O. A. Rhodes K. Groshen S. et al. Gene polymorphisms of epidermal growth factor receptor and its downstream effector interleukin-8 predict oxaliplatin efficacy in patients with advanced colorectal cancer[6] Ahuja S. K. Shetty A. Tiffany H. L. Murphy P. M. Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B.