INTERLEUKIN-8

The antibody can be used for inhibition of human and monkey IL-6 in bioassays. immuno precipitation and immuno assays. Furthermore the antibody is extremely useful in Western blots. The antibody reacts with human natural and recombinant Interleukin-8 (IL-8) as assessed by ELISA. The antibody inhibits the biological activity of human native and recombinant IL-8. The antibody cross reacts with rhesus and cynomolgus natural IL-8.

Homodimer.

Belongs to the intercrine alpha (chemokine CxC) family. [1] Kukielka G. L. Smith W. C. LaRosa G. J. Manning A. M. Mendoza L. H. Daly T. J. Hughes B. J. Youker K. A. Hawkins H. K. Michael L. H. et al. Interleukin-8 gene induction in the myocardium after ischemia and reperfusion in vivo[2] Kukielka G. L. et al. Direct Submission[3] Ishikawa J. Suzuki S. Hotta K. Hirota Y. Mizuno S. Suzuki K. Cloning of a canine gene homologous to the human interleukin-8-encoding gene. [4] Matsumoto Y. Mohamed A. Onodera T. Kato H. Ohashi T. Goitsuka R. Tsujimoto H. Hasegawa A. Furusawa S. Yoshihara K. et al. Molecular cloning and expression of canine interleukin 8 cDNA. [5] Kukielka G. L. Smith W. C. Larosa G. J. Manning A. M. Mendoza L. H. Daly T. J. Hughes B. J. Youker K. A. Hawkins H. K. Michael L. H. et al. Interleukin-8 gene induction in the myocardium after ischemia and reperfusion in vivo. [6] Straubinger R. K. Straubinger A. F. Harter L. Jacobson R. H. Chang Y. -F. Summers B. A. Erb H. N. Appel M. J. Borrelia burgdorferi migrates into joint capsules and causes an up-regulation of interleukin-8 in synovial membranes of dogs experimentally infected with ticks.