MOUSE ANTI HUMAN INTERLEUKIN-13:FITC

IL-13

Purified IgG prepared by ion exchange chromatography

Specifically recognises human interleukin-13 (IL-13) a 12. 5kDa immunoregulatory cytokine produced primarily by activated T helper type 2 (Th2) cells and also by mast cells and NK cells. IL-13 induces the stimulation of B cell proliferation and antibody production and studies suggest that IL-13 plays an important role in the induction of the pathophysiological features of allergic asthma independently of Immunoglobulin E (IgE) and eosinophils (1). Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROL:FITC

Gln-130 is a significant risk factor for asthma development. Gln/Gln at position 130 is associated with higher levels of serum total IgE than Arg/Arg in Chinese allergic rhinitis [MIM:607154] patients. Sequence similaritiesBelongs to the IL-4/IL-13 family. Caution: It is uncertain whether Met-1 or Met-15 is the initiator. Sequence cautionThe sequence AAA36107. 1 differs from that shown. Reason: Erroneous initiation. The sequence AAA83738. 1 differs from that shown. Reason: Erroneous initiation. The sequence AAB01681. 1 differs from that shown. Reason: Erroneous initiation. The sequence AAC03535. 1 differs from that shown. Reason: Erroneous initiation. The sequence AAK53823. 1 differs from that shown. Reason: Erroneous initiation. The sequence CAA48824. 1 differs from that shown. Reason: Erroneous initiation. [1] \" Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. \" Parrish-Novak J. Dillon S. R. Nelson A. Hammond A. Sprecher C. Gross J. A. Johnston J. Madden K. Xu W. West J. Schrader S. Burkhead S. Heipel M. Brandt C. Kuijper J. L. Kramer J. Conklin D. Presnell S. R. Berry J. Shiota F. Bort S. Hambly K. Mudri S. Clegg C. Moore M. Grant F. J. Lofton-Day C. Gilbert T. Raymond F. Ching A. Yao L. Smith D. Webster P. Whitmore T. Maurer M. Kaushansky K. Holly R. D. Foster D. Nature 408:57-63(2000) [PubMed: 11081504] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) FUNCTION SUBCELLULAR LOCATION TISSUE SPECIFICITY. [2] \" Cloning and characterization of an isoform of interleukin-21. \" Rahman M. Nara H. Onoda T. Araki A. Li J. Hoshino T. Asao H. FEBS Lett. 581:4001-4009(2007) [PubMed: 17673207] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). [3] SeattleSNPs variation discovery resourceSubmitted (SEP-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [4] \" Generation and annotation of the DNA sequences of human chromosomes 2 and 4. \" Hillier L. W. Graves T. A. Fulton R. S. Fulton L. A. Pepin K. H. Minx P. Wagner-McPherson C. Layman D. Wylie K. Sekhon M. Becker M. C. Fewell G. A. Delehaunty K. D. Miner T. L. Nash W. E. Kremitzki C. Oddy L. Du H. Sun H. Bradshaw-Cordum H. Ali J. Carter J. Cordes M. Harris A. Isak A. van Brunt A. Nguyen C. Du F. Courtney L. Kalicki J. Ozersky P. Abbott S. Armstrong J. Belter E. A. Caruso L. Cedroni M. Cotton M. Davidson T. Desai A. Elliott G. Erb T. Fronick C. Gaige T. Haakenson W. Haglund K. Holmes A. Harkins R. Kim K. Kruchowski S. S. Strong C. M. Grewal N. Goyea E. Hou S. Levy A. Martinka S. Mead K. McLellan M. D. Meyer R. Randall-Maher J. Tomlinson C. Dauphin-Kohlberg S. Kozlowicz-Reilly A. Shah N. Swearengen-Shahid S. Snider J. Strong J. T. Thompson J. Yoakum M. Leonard S. Pearman C. Trani L. Radionenko M. Waligorski J. E. Wang C. Rock S. M. Tin-Wollam A. -M. Maupin R. Latreille P. Wendl M. C. Yang S. -P. Pohl C. Wallis J. W. Spieth J. Bieri T. A. Berkowicz N. Nelson J. O. Osborne J. Ding L. Meyer R. Sabo A. Shotland Y. Sinha P. Wohldmann P. E. Cook L. L. Hickenbotham M. T. Eldred J. Williams D. Jones T. A. She X. Ciccarelli F. D. Izaurralde E. Taylor J. Schmutz J. Myers R. M. Cox D. R. Huang X. McPherson J. D. Mardis E. R. Clifton S. W. Warren W. C. Chinwalla A. T. Eddy S. R. Marra M. A. Ovcharenko I. Furey T. S. Miller W. Eichler E. E. Bork P. Suyama M. Torrents D. Waterston R. H. Wilson R. K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [5] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). [6] \" IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells. \" Strengell M. Julkunen I. Matikainen S. J. Leukoc. Biol. 76:416-422(2004) [PubMed: 15178704] [Abstract]Cited for: FUNCTION. [7] \" Interleukin-21 is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses. \" Sivakumar P. V. Foster D. C. Clegg C. H. Immunology 112:177-182(2004) [PubMed: 15147560] [Abstract]Cited for: REVIEW. [8] \" The existence of multiple conformers of interleukin-21 directs engineering of a superpotent analogue. \" Bondensgaard K. Breinholt J. Madsen D. Omkvist D. H. Kang L. Worsaae A. Becker P. Schioedt C. B. Hjorth S. A. J. Biol. Chem. 282:23326-23336(2007) [PubMed: 17565991] [Abstract]Cited for: STRUCTURE BY NMR OF 23-155 DISULFIDE BONDS.