MOUSE ANTI HUMAN INTERLEUKIN-8:FITC

GWB-834B98

IgG1

Tris - NaCl pH7. 4

Recombinant IL-8

IL-8 is a chemotactic factor that attracts neutrophils basophils and T-cells but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77) respectively. Ref. 15Ref. 24Ref. 27Subunit structureHomodimer. Subcellular locationSecreted. Post-translational modificationSeveral N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes leukcocytes and endothelial cells. In general IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form. Sequence similaritiesBelongs to the intercrine alpha (chemokine CxC) family. 1. Conejo-Garcia J. R. et al. (2001) Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity FASEB. J. 15: 1819-1821. [1] \" Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. \" Conejo-Garcia J. -R. Krause A. Schulz S. Rodriguez-Jimenez F. -J. Kluever E. Adermann K. Forssmann U. Frimpong-Boateng A. Bals R. Forssmann W. -G. FASEB J. 15:1819-1821(2001) [PubMed: 11481241] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] FUNCTION VARIANT VAL-10 TISSUE SPECIFICITY. Tissue: Lung. [2] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] VARIANT VAL-10.