METAP2 Polyclonal Antibody

A930035J23Rik, AI047573, AL024412, Amp2, AU014659, , EIF 2 associated p67 homolog, EIF-2-associated p67 , Initiation factor 2 associated 67 kDa glycoprotein, Initiation factor 2-associated 67 kDa glycoprotein, MAP 2, MAP2, MAP2, MetAP 2, Metap2, Methionine aminopeptidase 2, Methionyl aminopeptidase 2, MGC102452, MGC127390, MGC53792, MNPEP, p67, p67eIF2, Peptidase M, Peptidase M2

The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene.

Store at -20C. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

WB 1:200 - 1:2000

50kDa/52kDa