Recombinant Human Neprilysin(MME),partial

Cancer

Not Test

Homo sapiens (Human)

YDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKY ACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDV LQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEP LLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQL NSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGL PSRDYYECTGIYKEACTAYVDFMISVARLIRQEER LPIDENQLALEMNKVMELEKEIANATAKPEDRNDP MLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIM STVNISITNEEDVVVYAPEYLTKLKPILTKYSARD LQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGT TSETATWRRCANYVNGNMENAVGRLYVEAAFAGES KHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEE KALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDE YFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAV VNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYG GIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQS ASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLG ENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLN HKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGN FRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW

52-750aa

81.8 kDa

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids . Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond . Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 . Involved in the degradation of atrial natriuretic factor (ANF) . Displays UV-inducible elastase activity toward skin preelastic and elastic fibers .

Greater than 90% as determined by SDS-PAGE.

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids

Cell membrane, Single-pass type II membrane protein

Renin-angiotensinsystem