Recombinant Human Galectin-9(LGALS9)

Neuroscience

Not Test

Homo sapiens (Human)

MAFSGSQAPYLSPAVPFSGTIQGGLQDGLQITVNG TVLSSSGTRFAVNFQTGFSGNDIAFHFNPRFEDGG YVVCNTRQNGSWGPEERKTHMPFQKGMPFDLCFLV QSSDFKVMVNGILFVQYFHRVPFHRVDTISVNGSV QLSYISFQPPGVWPANPAPITQTVIHTVQSAPGQM FSTPAIPPMMYPHPAYPMPFITTILGGLYPSKSIL LSGTVLPSAQRFHINLCSGNHIAFHLNPRFDENAV VRNTQIDNSWGSEERSLPRKMPFVRGQSFSVWILC EAHCLKVAVDGQHLFEYYHRLRNLPTINRLEVGGD IQLTHVQT

1-323aa

65.9 kDa

Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil choattractant.

Greater than 90% as determined by SDS-PAGE.

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.

Binds galactosides

Peripheral blood leukocytes and lymphatic tissues. Expressed in lung, liver, breast and kidney with higher levels in tumor endothelial cells than normal endothelium (at protein level) (PubMed:24333696). Expressed in trophoblast cells in decidua and placenta in pregnancy (at protein level) (PubMed:23242525, PubMed:25578313). Isoform 2 is the most abundant isoform expressed in endothelial cells (PubMed:24333696). Upon endothelial cell activation isoform 2 expression decreases while expression of isoform 3 and isoform 5 increases (PubMed:24333696). Isoform 4 decreases in pathological pregnancy (PubMed:23242525).