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Recombinant Human Interleukin-17A protein(IL17A) (Active)

Recombinant Human Interleukin-17A protein(IL17A) (Active)

€156.00

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Item no.	CSB-AP001851HU-5
Manufacturer	Cusabio
Amount	5ug
Category	Metabolism Diabetes Glucose Homeostasis Peptides & Proteins Recombinant Proteins
Type	Proteins
Specific against	other
Host	E.coli
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	IL-17, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8
Available
Classification	Cytokine
Subdivision	Interleukin
Research Areas	Immunology
Uniprot NO.	Q16552
Uniprot Entry Name	IL17_HUMAN
Gene Names	IL17A, CTLA8, IL17
Source	E.Coli
Expression Region	24-155aa
Sequence	GITIPRNPGC PNSEDKNFPR TVMVNLNIHN RN TNTNPKRS SDYYNRSTSP WNLHRNEDPE RYPS VIWEAK CRHLGCINAD GNVDYHMNSV PIQQEI LVLR REPPHCPNSF RLEKILVSVG CTCVTPIV HH VA
Protein Description	Full Length of Mature Protein
Tag Info	Tag-Free
Mol. Weight	31.0 kDa
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 7.5 ng/ml, corresponding to a specific activity of ? 1.3 x 105 IU/mg.
Purity	>95% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
Alias	IL-17, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8
Relevance	Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.
PubMed ID	8676080; 7499828; 14574404; 15489334; 15340161; 19835883
Function	Ligand for IL17RA and IL17RC
Subcellular Location	Secreted
Protein Families	IL-17 family
Tissue Specificity	Restricted to activated memory T-cells.
Paythway	IL-17signalingpathway

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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