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Recombinant Human Interleukin-8 protein(CXCL8) (Active)

Recombinant Human Interleukin-8 protein(CXCL8) (Active)

€1,889.00

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Item no.	CSB-AP001761HU-500
Manufacturer	Cusabio
Amount	500ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Classification	Cytokine
Subdivision	Chemokine
Research Areas	Immunology
Uniprot NO.	P10145
Uniprot Entry Name	IL8_HUMAN
Gene Names	CXCL8, IL8
Source	E.Coli
Expression Region	28-99aa
Sequence	SAKELRCQCI KTYSKPFHPK FIKELRVIES GP HCANTEII VKLSDGRELC LDPKENWVQR VVEK FLKRAE NS
Protein Description	Partial
Tag Info	Tag-Free
Mol. Weight	8.4 kDa
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human CXCR2 transfected mouse BaF3 cells is less than 2 ng/ml, corresponding to a specific activity of ? 5.0 x105 IU/mg.
Purity	>97% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
Alias	IL-8, Chemokine C-X-C motif, ligand 8, Emoctakin, Granulocyte chemotactic protein 1
Relevance	IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. {ECO:0000269\|PubMed:11978786, ECO:0000269\|PubMed:2145175, ECO:0000269\|PubMed:2212672}.
PubMed ID	2664463
Function	IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
Subcellular Location	Secreted
Protein Families	Intercrine alpha (chemokine CxC) family
Paythway	Chemokinesignalingpathway

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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