Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4(CTLA4),partial (Active)

Drug Target

Immunology

CTLA4

37-161aa

Partial

14.1 kDa

Greater than 90% as determined by SDS-PAGE.

0.2 um Filtered 1xPBS, pH 7.4

Cytotoxic Tlymphocyte 4(CTLA-4, CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.