CYBB Antibody

CYBB, CGD, GP91-1, GP91-PHOX, GP91PHOX, NOX2, p91-PHOX

P04839

ELISA, WB, IHC, WB:1:500-1:2000, IHC:1:50-1:200

WB:1:500-1:2000

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase, neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cells respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Affinity purification

Cancer, Immunology?Metabolism